Cross-protection studies with H5 influenza viruses
Identifieur interne : 001846 ( Main/Exploration ); précédent : 001845; suivant : 001847Cross-protection studies with H5 influenza viruses
Auteurs : Yuri A. Smirnov [Russie] ; Nikolai V. Kaverin [Russie] ; Elena A. Govorkova [Russie] ; Alexander S. Lipatov [Russie] ; Eric C. J. Claas [Pays-Bas] ; Natalia V. Makarova [Russie] ; Asya K. Gitelman [Russie] ; Robert G. Webster [États-Unis] ; Dmitri K. Lvov [Russie]Source :
- International congress series [ 0531-5131 ] ; 2001.
English descriptors
- Teeft :
- Accession number, Acta virol, Allantoic fluid, American lineage, Antigenic, Antigenic variants, Avian, Avian influenza, Avian influenza viruses, Challenge virus, Elsevier science, Eurasian, Eurasian viruses, Hemagglutinin, High level, Hong kong, Immunization, Influenza, Influenza virus, Influenza viruses, Influenza viruses encoding, International congress series, Kawaoka, Lethal challenge, Lineage, Mabs, Monoclonal antibodies, Mouse model, Nucleotide sequences, Phylogenetic, Phylogenetic analysis, Phylogenetic relationships, Phylogenetic tree, Present study, Protective efficacy, Protective immunity, Smirnov, Survival rates, Vaccine, Virol, Virology, Virus.
Abstract
Abstract: Background: The direct transmission of avian influenza H5N1 virus from infected poultry into humans raised questions about the level of protection induced by different strains within the H5 subtype. Methods: In this study, the hemagglutinins (HA) of four avian H5 viruses and the human A/Hong Kong/156/97 (H5N1) strain were analyzed antigenically and their phylogenetic relationships were established. These viruses were further characterized in cross-protection studies in mice. Mice were immunized with β-propiolactone-inactivated viruses, and three weeks later challenged with 10 MLD50 of the mouse-adapted A/Mallard Duck/Pennsylvania/10218/84. Results: The HI test with a panel of HA-specific monoclonal antibodies showed different reactivity patterns for the five H5 influenza viruses studied. Phylogenetic analysis revealed genetic diversity among these H5 viruses as well. Cross-protection experiments indicated that mice immunized with American viruses exhibited a high level of protection (94.4–100.0%) against challenge with the virus from the same phylogenetic lineage. Immunization with Eurasian viruses induced lower levels of protection in mice (50.0–55.5%). Conclusions: Due to the heterogeneity of the H5 viruses, no single broad reactive strain is available as an appropriate vaccine candidate for a potential H5 influenza pandemic.
Url:
DOI: 10.1016/S0531-5131(01)00356-9
Affiliations:
- Pays-Bas, Russie, États-Unis
- District fédéral central, Hollande-Méridionale, Tennessee
- Leyde, Moscou
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: Background: The direct transmission of avian influenza H5N1 virus from infected poultry into humans raised questions about the level of protection induced by different strains within the H5 subtype. Methods: In this study, the hemagglutinins (HA) of four avian H5 viruses and the human A/Hong Kong/156/97 (H5N1) strain were analyzed antigenically and their phylogenetic relationships were established. These viruses were further characterized in cross-protection studies in mice. Mice were immunized with β-propiolactone-inactivated viruses, and three weeks later challenged with 10 MLD50 of the mouse-adapted A/Mallard Duck/Pennsylvania/10218/84. Results: The HI test with a panel of HA-specific monoclonal antibodies showed different reactivity patterns for the five H5 influenza viruses studied. Phylogenetic analysis revealed genetic diversity among these H5 viruses as well. Cross-protection experiments indicated that mice immunized with American viruses exhibited a high level of protection (94.4–100.0%) against challenge with the virus from the same phylogenetic lineage. Immunization with Eurasian viruses induced lower levels of protection in mice (50.0–55.5%). Conclusions: Due to the heterogeneity of the H5 viruses, no single broad reactive strain is available as an appropriate vaccine candidate for a potential H5 influenza pandemic.</div>
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